Faculty & Research
- Contact Information
- Contact Marcy Kingsbury by mk24 [at] indiana [dot] edu
- By telephone: 812-856-2391
- By fax: 812-855-6705
- JH A013
- Research Areas
Ph.D. Cornell University, 2000
Postdoctoral Fellow, UC San Diego, 2000-2003
Postdoctoral Fellow, The Scripps Research Institute, 2003-2007
Our research is focused on the structure and function of social behavior circuitry in the brain. Of particular interest are variations in structure and function that produce individual, sex, species and seasonal differences in behavior. Much of the behavioral diversity that we observe is produced by variation in gene expression rather than by large-scale reorganizations of social circuitry or major differences in anatomy. In fact, the core components of the brain's "social behavior network" are strikingly similar across vertebrate groups. Most of our work is conducted in socially diverse species of songbirds, including estrildid finches and emberizid sparrows. The estrildid finch family offers a unique ability to determine how neural and motivational processes have evolved in relation to sociality since species from this family display large variation in group sizes but are matched in other aspects of behavior and ecology.
Our work has focused on the nonapeptides vasotocin and mesotocin, which are homologues of the mammalian neuropeptides vasopressin and oxytocin. We have identified anatomical and functional properties of nonapeptide circuits that closely match individual, sex, and species differences in behavior. We have also manipulated nonapeptide systems and shown that we can influence an individual’s choice of group size, independent of that individual’s decision to be social. Other studies in our lab have demonstrated that these nonapeptides are important modulators of additional behaviors such as aggression, pair bonding, and anxiety-like behavior.
In addition to vasotocin and mesotocin, we have examined other neuropeptides and enzymes, including tyrosine hydroxylase, aromatase, corticotropin releasing hormone and vasoactive intestinal polypeptide (VIP), all of which appear to be relevant to individual, species and seasonal differences in social structure.
Of these, the neuromodulator VIP is currently a focus of ongoing lab studies since VIP cells, fibers and receptors are found in virtually every brain region that is important for social behavior. However, few studies have examined the behavioral functions of this peptide outside of its role as the main regulator of prolactin secretion from the pituitary. We are currently investigating whether VIP circuits may be variably important for grouping behavior, aggression, pair bonding, social anxiety and parental care in the gregarious zebra finch under support from the National Institutes of Health.
- Kingsbury, M. A. and Goodson, J. L. (2014) Pair bond formation is impaired by VPAC receptor antagonism in the socially monogamous zebra finch. Behav. Brain Res. 272: 264-268. PMID: 25014003
- Goodson, J. L. and Kingsbury, M. A. (2013) What's in a name? Considerations of homologies and nomenclature for vertebrate social behavior networks. Horm. Behav. 64: 103-112. PMID 2372238.
- Kingsbury, M. A., Miller, K. M., and Goodson, J. L. (2013) VPAC receptor signaling modulates grouping behavior and social responses to contextual novelty in a gregarious finch: a role for a putative prefrontal cortex homologue. Horm. Behav. 64: 511-518. PMID 22759599.
- Goodson, J. L., Kelly, A. M., Kingsbury, M. A., and Thompson, R. R. (2012) An aggression-specific cell type in the anterior hypothalamus of finches. Proc. Natl. Acad. Sci. U. S. A. 109: 13847-13852. PMID: 22872869.
- Goodson, J. L., and Kingsbury, M. A. (2012) Evolving nonapeptide mechanisms of gregariousness and social diversity in birds. Horm. Behav. 61: 239-250. PMID: 22269661.
- Kingsbury, M. A., Gleason, E. D., Ophir, A. G., Phelps, S. M., Young, L. J., and Marler, C. A. (2012) Monogamous and promiscuous rodent species exhibit discrete variation in the size of medial prefrontal cortex. Brain Behav. Evol. 80: 4-14. PMID: 23899763.
- Goodson, J. L., and Kingsbury, M. A. (2011) Nonapeptides and the evolution of social group sizes in birds. Front. Neuroanat. 5: 13. PMID: 21427780.
- Kelly, A. M., Kingsbury, M. A., Hoffbuhr, K., Schrock, S. E., Waxman, B., Kabelik, D., Thompson, R. R., and Goodson, J. L. (2011) Vasotocin neurons and septal V1a-like receptors potently modulate songbird flocking and responses to novelty. Horm. Behav. 60: 12-21. PMID: 21295577.
- Kingsbury, M. A., Kelly, A. K., Schrock, S. E., and Goodson, J. L. (2011) Mammal-like organization of the avian midbrain central gray and a reappraisal of the intercollicular nucleus. PLoS ONE 6: e20720. PMID: 21694758.
- Goodson, J. L., Schrock, S. E., Klatt, J. D., Kabelik, D., and Kingsbury, M. A. (2009) Mesotocin and nonapeptide receptors promote songbird flocking behavior. Science 325: 862-866. PMID: 2862247.